PKD2 Antibody - Cat. #: CSB-PA618787LA01HU

SKU: CSB-PA618787LA01HU

Size :50ug

Clone Number:

Aliases:APKD2 antibody; Autosomal dominant polycystic kidney disease type II antibody; Autosomal dominant polycystic kidney disease type II protein antibody; MGC138466 antibody; MGC138468 antibody; PC 2 antibody; PC2 antibody; PKD 2 antibody; PKD2 antibody; PKD2_HUMAN antibody; PKD4 antibody; Polycystic kidney disease 2 (autosomal dominant) antibody; Polycystic kidney disease 2 antibody; Polycystic kidney disease 2 protein antibody; Polycystin 2 antibody; Polycystin 2 transient receptor potential cation channel antibody; Polycystin-2 antibody; Polycystin2 antibody; Polycystwin antibody; R48321 antibody; Transient receptor potential cation channel subfamily P member 2 antibody; TRPP2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13563

Immunogen:Recombinant Human Polycystin-2 protein (680-968AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PKD2

Research Areas:Metabolism; Signal transduction