PITX3 Antibody, Biotin conjugated - Cat. #: CSB-PA010844LD01HU

SKU: CSB-PA010844LD01HU

Size :50ug

Clone Number:

Aliases:Homeobox protein PITX 3 antibody; Homeobox protein PITX3 antibody; MGC12766 antibody; Paired like homeodomain transcription factor 3 antibody; Paired-like homeodomain transcription factor 3 antibody; Pituitary homeobox 3 antibody; PITX 3 antibody; Pitx3 antibody; PITX3_HUMAN antibody; PTX 3 antibody; PTX3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75364

Immunogen:Recombinant Human Pituitary homeobox 3 protein (10-200AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PITX3

Research Areas:Epigenetics and Nuclear Signaling; Neuroscience