Phospho-RELB (Ser573) Antibody - Cat. #: CSB-PA869552

SKU: CSB-PA869552

Size :100ul

Clone Number:

Aliases:I REL antibody; I-Rel antibody; IREL antibody; Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 antibody; relB antibody; RELB_HUMAN antibody; Reticuloendotheliosis viral oncogene homolog B antibody; Transcription factor Rel B antibody; Transcription factor RelB antibody; v rel avian reticuloendotheliosis viral oncogene homolog B antibody; v rel reticuloendotheliosis viral oncogene homolog B antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q01201

Immunogen:Peptide sequence around phosphorylation site of serine 573 (L-L-S(p)-P-G) derived from Human RelB.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:100

Background:NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.

Marienfeld R, et al. (2001) Oncogene. 20 (56): 8142-7.
Charlotte S. Kaetzel1, et al. (2005) Immunological Reviews Volume 206: 83
Elwira Pyz, et al. (2006) J Immunol. 176:7447-55

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RELB

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology;Signal transduction