Phospho-PIN1 (Ser16) Antibody - Cat. #: CSB-PA801966

SKU: CSB-PA801966

Size :100ul

Clone Number:

Aliases:DOD antibody; DODO, Drosophila, homolog of antibody; FLJ40239 antibody; FLJ77628 antibody; MGC10717 antibody; NIMA interacting 1 antibody; Peptidyl prolyl cis trans isomerase NIMA interacting 1 antibody; Peptidyl prolyl cis/trans isomerase NIMA interacting antibody; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody; Peptidyl-prolyl cis-trans isomerase pin1 antibody; Peptidylprolyl cis/trans isomerase NIMA interacting 1 antibody; Pin 1 antibody; Pin1 antibody; PIN1_HUMAN antibody; PPIase Pin1 antibody; Prolyl isomerase antibody; Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1 antibody; Protein NIMA interacting 1 antibody; Rotamase Pin1 antibody; UBL 5 antibody; UBL5 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13526

Immunogen:Peptide sequence around phosphorylation site of serine16(R-M-S(p)-R-S) derived from Human Pin1 .

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner.

Lee YC, et al. (2013)J Cell Sci 126, 4862-72. Ando K, et al. (2013)Neurobiol Aging 34, 757-69. Nechama M, Lin CL, Richter JD (2013)Mol Cell Biol 33, 48-58.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PIN1

Research Areas:Neuroscience;Cell biology