Phospho-CHEK2 (Thr68) Polyclonal Antibody

SKU: E-AB-20843

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Acetyl/Phospho/Methyl Antibodies

Abbreviation: Chk2 (phospho Thr68)

Target Synonym: CDS 1;Cds1;Cds1 homolog;Checkpoint kinase 2;Checkpoint like protein CHK2;CHEK 2;Chek2;Chk 2;CHK2 checkpoint homolog (S. pombe);CHK2 checkpoint homolog;CHK2;hCds1;HuCds 1;LFS 2;LFS2;PP1425;RAD 53;RAD53;Rad53 homolog;Serine/threonine protein kinase Chk2;Serine/threonine-protein kinase Chk2

Research Areas: Cancer;Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: WB;IHC-p;IF

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: O96017

Accession:

Background: Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.

Concentration: 1 mg/mL

Immunogen: Synthesized peptide derived from human Chk2 around the phosphorylation site of Thr68

Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Purification method: Affinity purification

Dilution: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:50-1:200

Calculated MW: 61kDa

ObservedMW: 61kDa