Phospho-CDKN1A (Thr145) Antibody - Cat. #: CSB-PA074462

SKU: CSB-PA074462

Size :100ul

Clone Number:

Aliases:CAP20 antibody; CDK-interacting protein 1 antibody; CDKI antibody; CDKN1 antibody; Cdkn1a antibody; CDN1A_HUMAN antibody; CIP1 antibody; Cyclin Dependent Kinase Inhibitor 1A antibody; Cyclin-dependent kinase inhibitor 1 antibody; Cyclin-dependent kinase inhibitor 1A (P21) antibody; Cyclin-dependent kinase inhibitor 1A (p21, Cip1) antibody; DNA Synthesis Inhibitor antibody; MDA-6 antibody; MDA6 antibody; Melanoma differentiation-associated protein 6 antibody; Melanoma differentiation-associated protein antibody; p21 antibody; P21 protein antibody; p21CIP1 antibody; p21Cip1/Waf1 antibody; p21WAF antibody; PIC1 antibody; SDI1 antibody; SLC12A9 antibody; WAF1 antibody; Wild type p53 activated fragment 1 (WAF1) antibody; Wild type p53 activated fragment 1 antibody; Wildtype p53-activated fragment 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P38936

Immunogen:Peptide sequence around phosphorylation site of threonine 145 (R-Q-T(p)-S-M) derived from Human p21Cip1.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; IHC:1:50-1:100

Background:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.

Ocker M Int,et al. (2007)J Biochem Cell Biol. 39(7-8):1367-74.
Dangi S, et al.(2006)Cell Prolif. 39(4):261-79.
Chen J,et al.(2006)Am J Physiol Heart Circ Physiol. 290(4):H1575-86

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CDKN1A

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology