Phospho-Caldesmon (S789) Polyclonal Antibody

SKU: BT-PHS00874

Size:100μL

Background:CALD1 encodes a calmodulin- and actin-binding protein (caldesmon 1) that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca (2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca (2+)- dependent inhibition of smooth muscle contraction. Alternative splicing of CALD1 results in multiple transcript variants encoding distinct isoforms.

Research_area:Signal Transduction; Cardiovascular

Target_protein:CALD1

applications:WB, IHC-p, IF, ELISA

Reactivity:Human, mouse, rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Phospho-Caldesmon (S789) Antibody

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):high molecular weight (predominantly in smooth muscles) (120-150 KD) and a low molecular weight (60

UniProt accession:Human: Q05682; Rat: Q62736

Synonyms:CALD1; CAD; CDM; Caldesmon; CDM

GeneID:Human: 800; Rat: 25687