Phospho-BLNK (Tyr96) Antibody - Cat. #: CSB-PA598542

SKU: CSB-PA598542

Size :100ul

Clone Number:

Aliases:AGM4 antibody; B cell adapter containing SH2 domain protein antibody; B cell adapter containing Src homology 2 domain protein antibody; B cell adaptor containing SH2 domain antibody; B cell linker antibody; B cell linker protein antibody; B cell-specific adaptor protein antibody; B-cell activation antibody; B-cell adapter containing a SH2 domain protein antibody; B-cell adapter containing a Src homology 2 domain protein antibody; B-cell linker protein antibody; BASH antibody; Bca antibody; BLNK antibody; BLNK s antibody; BLNK_HUMAN antibody; Cytoplasmic adapter protein antibody; Ly 57 antibody; Ly57 antibody; Lymphocyte antigen 57 antibody; Lyw 57 antibody; Lyw57 antibody; MGC111051 antibody; SH2 domain-containing leukocyte protein; 65-KD antibody; SLP 65 antibody; SLP-65 antibody; SLP65 antibody; Src homology [SH2] domain-containing leukocyte protein of 65 kD antibody; Src homology 2 domain containing leukocyte protein of 65 kDa antibody; Src homology 2 domain-containing leukocyte protein of 65 kDa antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8WV28

Immunogen:Peptide sequence around phosphorylation site of tyrosine 96(D-S-Y(p)-E-P) derived from Human BLNK .

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling.

Wang X, et al. (2012)J Biol Chem 287, 11037-48. Patterson HC, et al. (2006)Immunity 25, 55-65 . Chiu CW, et al. (2002)EMBO J 21, 6461-72.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:BLNK

Research Areas:Immunology;Signal transduction