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Gene Bio Systems

PAWR Antibody - Cat. #: CSB-PA041090

PAWR Antibody - Cat. #: CSB-PA041090

CSB-PA041090

£512.00 GBP
£512.00 GBP
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Size :100ul

Clone Number:

Aliases:2310001G03Rik antibody; PAR 4 antibody; PAR-4 antibody; Pawr antibody; PAWR_HUMAN antibody; PRKC Apoptosis WT1 Regulator antibody; PRKC apoptosis WT1 regulator protein antibody; Prostate apoptosis response 4 protein antibody; Prostate apoptosis response protein 4 antibody; prostate apoptosis response protein PAR-4 antibody; Transcriptional repressor Par-4-like protein PAWR antibody; Transcriptional repressor PAR4 antibody; WT1 Interacting Protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96IZ0

Immunogen:Synthesized peptide derived from Human prostate apoptosis response protein-4.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Hongzhe Li, J. Biol. Chem., Feb 2007; 282: 4943 - 4950.
Wuhan Xiao, Cancer Res., Aug 2003; 63: 4698 - 4704.
Thierry Virolle, J. Biol. Chem., Mar 2003; 278: 11802 - 11810.
Derek J. Richard, Genes & Dev., Feb 2001; 15: 328.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PAWR

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology;Metabolism

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