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Gene Bio Systems

PARN Antibody - Cat. #: CSB-PA017456LA01HU

PARN Antibody - Cat. #: CSB-PA017456LA01HU

CSB-PA017456LA01HU

£287.00 GBP
£287.00 GBP
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Size :50ug

Clone Number:

Aliases:DAN antibody; Deadenylating nuclease antibody; Deadenylation nuclease antibody; PARN antibody; PARN_HUMAN antibody; Poly A specific ribonuclease antibody; Poly(A) specific ribonuclease antibody; Poly(A)-specific ribonuclease PARN antibody; Polyadenylate specific ribonuclease antibody; Polyadenylate-specific ribonuclease antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O95453

Immunogen:Recombinant Human Poly(A)-specific ribonuclease PARN protein (1-639AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background:3\\\'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3\\\'-end poly(A) tail and the 5\\\'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3\\\'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PARN

Research Areas:Epigenetics and Nuclear Signaling

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