p21 (Acetyl Lys161/K163) Rabbit Polyclonal Antibody

SKU: BT-AP11698

Size:100μL

Background:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity| preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.|induction:By p53| mezerein (antileukemic compound) and interferon beta.|PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.|Belongs to the CDI family.|tissue specificity:Expressed in all adult human tissues| with 5-fold lower levels observed in the brain.|

Research_area:Cancer; Cell biology; Epigenetics and nuclear signaling; Signal transduction

Target_protein:CDKN1A

applications:WB, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:p21

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):18040

UniProt accession:Human: P38936; Mouse: P39689

Synonyms:p21 ;Acetyl Lys161/K163; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21

GeneID:Human: 1026; Mouse: 12575