OCT-4 Monoclonal Antibody

SKU: BT-MCA4034

Size:100μL

Background:Oct4: octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3/4, also known as POU5F1(POU class 5 homeobox 1), octamerbinding transcription factor-3 (Oct-3, Otf-3), modulates embryonic stem (ES) cell populations by influencing lineage commitment. Entrez Protein NP_002692. Oct-3/4 sustains stem-cell selfrenewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.

Research_area:Others

Target_protein:OCT-4

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:1D10H6

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:OCT-4

Immunogen:Purified recombinant fragment of Oct4 (aa193-360) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):38.5kDa

UniProt accession:Q01860

Synonyms:OCT3, OTF3, OTF4, MGC22487, POU5F1

GeneID:5460