Nucleophosmin Monoclonal Antibody

SKU: BT-MCA3151

Size:100μL

Background:Nucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities. The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.

Research_area:Others

Target_protein:Nucleophosmin

applications:WB, IHC, ICC

Reactivity:Human, Monkey

Clonality:Monoclonal

Clone ID:7H10B9

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:Nucleophosmin

Immunogen:Purified recombinant fragment of human NPM (2-265) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):33kDa

UniProt accession:P06748

Synonyms:B23, NPM

GeneID:4869