NR3C1 (Ab-211) Antibody - Cat. #: CSB-PA784840

SKU: CSB-PA784840

Size :100ul

Clone Number:

Aliases:GCCR antibody; GCR antibody; GCR_HUMAN antibody; GCRST antibody; glucocorticoid nuclear receptor variant 1 antibody; Glucocorticoid receptor antibody; GR antibody; GRL antibody; Grl1 antibody; nr3c1 antibody; Nuclear receptor subfamily 3 group C member 1 antibody; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P04150

Immunogen:Synthesized non-phosphopeptide derived from Human GR around the phosphorylation site of serine 211 (N-E-S-P-W).

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

Background:Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

Zhen Wang, Mol. Endocrinol., Mar 2007; 21: 625 - 634.
Aaron L. Miller, Mol. Endocrinol., Jun 2005; 19: 1569 - 1583.
Paul J. LeBlanc, J. Physiol., Jun 2004; 557: 559 - 570.
JosXavier-Neto, Hypertension, Jul 1999; 34: 31.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NR3C1

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Signal transduction