NR1H3 antibody , Cat. # FNab05836

SKU: FNab05836

Size:100ug

Purification:Protein A+G purification

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Mouse

Clonality:monoclonal

Clone ID:7D2

Isotype:IgG2a

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism(By similarity). Exhibits a ligand-dependent transcriptional activation activity(PubMed:25661920).

Immunogen:nuclear receptor subfamily 1, group H, member 3

Synonyms:Liver X receptor alpha, LXR a, LXRA, NR1H3, Oxysterols receptor LXR alpha, RLD 1

Observed MW:48 kDa

Uniprot ID:Q13133

Reactivity:Human, Rat

Tested Application:ELISA, WB, IF

Recommended dilution:WB: 1:200-1:1000; IF: 1:10-1:100

Gene ID:10062

Research Area:Neuroscience, Cardiovascular, Metabolism, Signal Transduction