NR1H2 Monoclonal Antibody

SKU: BT-MCA4113

Size:100μL

Background:The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).

Research_area:Cardiovascular, Epigenetics and nuclear signaling, Metabolism

Target_protein:NR1H2

applications:ICC, FCM

Reactivity:

Clonality:Monoclonal

Clone ID:5C11D3

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:NR1H2

Immunogen:Purified recombinant fragment of human NR1H2 (AA:1-200) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):51kDa

UniProt accession:P55055

Synonyms:NER, UNR, LXRB, LXR-b, NER-I, RIP15

GeneID:7376