NPHS1 Antibody - Cat. #: CSB-PA967591

SKU: CSB-PA967591

Size :50ul

Clone Number:

Aliases:CNF antibody; Nephrin antibody; Nephrosis 1 congenital Finnish type antibody; Nephrosis 1, congenital, Finnish type (nephrin) antibody; NPHN antibody; NPHN_HUMAN antibody; NPHS 1 antibody; Nphs1 antibody; Renal glomerulus specific cell adhesion receptor antibody; Renal glomerulus-specific cell adhesion receptor antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O60500

Immunogen:Synthetic peptide of Human NPHS1

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

Background:This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180-kDa protein in lysates of human glomeruli and a 150-kDa protein in transfected COS-7 cell lysates.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NPHS1

Research Areas:Signal transduction