NP Antibody, HRP conjugated - Cat. #: CSB-PA325769LB01IIM

SKU: CSB-PA325769LB01IIM

Size :50ug

Clone Number:

Aliases:NP antibody; Nucleoprotein antibody; Nucleocapsid protein antibody; Protein N antibody

Product Type:Polyclonal Antibody

Immunogen Species:Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))

UniProt ID:P15682

Immunogen:Recombinant Influenza A virus Nucleoprotein protein (1-498AA)

Raised in:Rabbit

Species Reactivity:Influenza A virus

Tested Applications:ELISA

Background:Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein\'s nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein\'s nuclear localization signals, targeting the RNP to the nucleus (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NP

Research Areas:Others