NOD2 Antibody, HRP conjugated - Cat. #: CSB-PA881021LB01HU

SKU: CSB-PA881021LB01HU

Size :50ug

Clone Number:

Aliases:ACUG antibody; Arthrocutaneouveal granulomatosis antibody; BLAU antibody; CARD15 antibody; Caspase recruitment domain family, member 15 antibody; Caspase recruitment domain protein 15 antibody; Caspase recruitment domain-containing protein 15 antibody; CD antibody; CLR16.3 antibody; IBD1 antibody; Inflammatory bowel disease protein 1 antibody; LRR containing protein antibody; NLR family, CARD domain containing 2 antibody; NLRC2 antibody; NOD like receptor C2 antibody; NOD2 antibody; NOD2 protein antibody; NOD2_HUMAN antibody; NOD2B antibody; nucleotide binding oligomerization domain 2 antibody; Nucleotide binding oligomerization domain containing 2 antibody; Nucleotide binding oligomerization domain, leucine rich repeat and CARD domain containing 2 antibody; Nucleotide-binding oligomerization domain-containing protein 2 antibody; PSORAS1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9HC29

Immunogen:Recombinant Human Nucleotide-binding oligomerization domain-containing protein 2 protein (460-733AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NOD2

Research Areas:Cell biology