N Antibody - Cat. #: CSB-PA318401LA01LNP

SKU: CSB-PA318401LA01LNP

Size :50ug

Clone Number:

Aliases:N antibody; Nucleoprotein antibody; EC 3.1.13.- antibody; Nucleocapsid protein antibody; Protein N antibody

Product Type:Polyclonal Antibody

Immunogen Species:Lassa virus

UniProt ID:P13699

Immunogen:Recombinant Lassa virus Nucleoprotein protein (1-569AA)

Raised in:Rabbit

Species Reactivity:Lassa virus

Tested Applications:ELISA

Background:Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:N

Research Areas:Others