MTOR Polyclonal Antibody

SKU: E-AB-70304

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:MTOR

Target Synonym:dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1);FK506 binding protein 12 rapamycin associated protein 1;FK506 binding protein 12 rapamycin associated protein 2;FK506 binding protein 12 rapamycin complex associated protein 1;FK506-binding protein 12-rapamycin complex-associated protein 1;FKBP rapamycin associated protein;FKBP12 rapamycin complex associated protein;FKBP12-rapamycin complex-associated protein 1;FKBP12-rapamycin complex-associated protein;FLJ44809;FRAP;FRAP1;FRAP2;Mammalian target of rapamycin;Mechanistic target of rapamycin;mTOR;MTOR;OTTHUMP00000001983;RAFT1;Rapamycin and FKBP12 target 1;Rapamycin associated protein FRAP2;Rapamycin target protein 1;Rapamycin target protein;RAPT1;Serine/threonine-protein kinase mTOR

Research Areas:Cancer;Cell Biology;Cardiovascular;Epigenetics and Nuclear Signaling;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P42345,Q9JLN9,P42346

Accession:

Background:MTOR, also named as FRAP1, FRAP, FRAP2 and RAPT1, belongs to the PI3/PI4-kinase family. MTOR is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. MTOR is Kinase subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. The antibody is specific to MTOR.

Concentration:0.8 mg/mL

Immunogen:Recombinant protein corresponding to Mouse mTOR

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification method:Affinity purification

Dilution:WB 1:500-1:2000

Calculated MW:289kDa

ObservedMW:289kDa