MRE11 Antibody - Cat. #: CSB-PA014786ESR1HU

SKU: CSB-PA014786ESR1HU

Size :50ul

Clone Number:

Aliases:AT like disease antibody; Ataxia telangiectasia disorder like antibody; ATLD antibody; DNA recombination and repair protein antibody; Double strand break repair protein MRE11A antibody; Double-strand break repair protein MRE11A antibody; endo/exonuclease Mre11 antibody; HNGS1 antibody; meiotic recombination (S. cerevisiae) 11 homolog A antibody; Meiotic recombination 11 homolog 1 antibody; meiotic recombination 11 homolog A (S. cerevisiae) antibody; Meiotic recombination 11 homolog A antibody; MmMRE11A antibody; Mre 11 antibody; MRE 11a antibody; MRE 11b antibody; MRE11 homolog 1 antibody; MRE11 homolog A antibody; MRE11 homolog double strand break repair nuclease antibody; MRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibody; MRE11 meiotic recombination 11 homolog A antibody; MRE11_HUMAN antibody; MRE11A antibody; MRE11b antibody; OTTHUMP00000236830 antibody; OTTHUMP00000236831 antibody; OTTHUMP00000236832 antibody; OTTHUMP00000236833 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P49959

Immunogen:Recombinant Human Double-strand break repair protein MRE11 protein (1-205AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background:Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3\\\'-5\\\' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MRE11

Research Areas:Epigenetics and Nuclear Signaling