Mouse VGF nerve growth factor inducible,VGF ELISA KIT

SKU: E2705Mo

Size:96 Tests-1 Kit

Background:[Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (PubMed:19863797, PubMed:26180209, PubMed:30504797). {ECO:0000250|UniProtKB:P20156, ECO:0000269|PubMed:19863797, ECO:0000269|PubMed:26180209, ECO:0000269|PubMed:30504797}.; [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. {ECO:0000250|UniProtKB:P20156}.; [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity). {ECO:0000250|UniProtKB:P20156}.; [VGF-derived peptide TLQP-21]: Secreted multifunctional peptide that interacts with different receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation as well as lipolysis (PubMed:22289198, PubMed:25456411). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (PubMed:25456411). Interacts with gC1qR receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000269|PubMed:22289198, ECO:0000269|PubMed:25456411}.; [VGF-derived peptide TLQP-62]: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (PubMed:26180209, PubMed:30504797). Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (PubMed:25917832). {ECO:0000269|PubMed:25917832, ECO:0000269|PubMed:26180209, ECO:0000269|PubMed:30504797}.

Research_area:

Applications:ELISA

Target_protein:Vgf

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:7.61ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:VGF nerve growth factor inducible

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q0VGU4

MASS(Da):68232

GeneID:381677

Synonyms:Vgf

Gene names:Vgf

Standard solution:3200ng/L