Mouse Suppressors of Cytokine Signaling 1, SOCS-1 ELISA Kit

SKU: E2496Mo

Size:96 Tests-1 Kit

Background:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway (PubMed:15522878). Through binding to JAKs and IFNGR1, inhibits their kinase activity (PubMed:9202125). In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF) (PubMed:9202125). Regulates interferon-gamma (IFNG) mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (By similarity). SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity).

Research_area:Immunology; Signal Transduction; Epigenetics and Nuclear Signaling; Stem Cells; Cancer; Metabolism

Applications:ELISA

Target_protein:SOCS-1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:12.01ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:suppressors of cytokine signaling 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O35716

MASS(Da):23,715

GeneID:12703

Synonyms:Cis;Cish1;JA;JAB;JAK-binding protein;SOC;SOCS-1;SS;SSI-1;STAT-induced STAT inhibitor 1;Suppressor of cytokine signaling 1

Gene names:Socs1

Standard solution:8000ng/L