Mouse Stimulated by retinoic acid gene 6 protein homolog,STRA6 ELISA KIT

SKU: E2491Mo

Size:96 Tests-1 Kit

Background:Functions as retinol transporter (PubMed:23839944, PubMed:24852372). Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (By similarity). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:23839944). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid and 11-cis-retinal (PubMed:22467576, PubMed:24852372). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (PubMed:22467576, PubMed:23839944, PubMed:24852372). Does not transport retinoic acid (By similarity). {ECO:0000250|UniProtKB:Q9BX79, ECO:0000269|PubMed:21368206, ECO:0000269|PubMed:22467576, ECO:0000269|PubMed:23839944, ECO:0000269|PubMed:24852372}.

Research_area:

Applications:ELISA

Target_protein:Stra6

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:1.58ng/L

Detection range:3-900ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Stimulated by retinoic acid gene 6 protein homolog

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O70491

MASS(Da):73775

GeneID:20897

Synonyms:Stra6

Gene names:Stra6

Standard solution:960ng/L