Mouse Serpin D1 ELISA Kit PicoKine®

SKU: EK1969

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: Serpind1

Specificity: Natural and recombinant mouse Serpin D1

Background: Heparin cofactor II (HCII), a protein encoded by the SERPIND1 gene, is a coagulation factor that inhibits IIa, and is a cofactor for heparin and dermatan sulfate. It is mapped to 16 A3; 16 10.74 cM. This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency.

Immunogen: Expression system for standard: NS0; Immunogen sequence: E24-S478

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Reference:

Uniprot ID: P49182

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 15160

Protein Name: Heparin cofactor 2

Gene Full Name: serine (or cysteine) peptidase inhibitor, clade D, member 1

Synonyms: D22S673; HC II; HC2; HCF2; HCII; Heparin cofactor 2; Heparin cofactor II; HLS2; LS2; Protease inhibitor leuserpin 2; Serpin D1; SERPIND1