Mouse Rho Guanine Nucleotide Exchange Factor 2,ARHGEF2 ELISA KIT

SKU: E1358Mo

Size:96 Tests-1 Kit

Background:Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (PubMed:28453519). {ECO:0000250|UniProtKB:Q865S3, ECO:0000250|UniProtKB:Q92974, ECO:0000269|PubMed:28453519}.

Research_area:

Applications:ELISA

Target_protein:Arhgef2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.1ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Rho Guanine Nucleotide Exchange Factor 2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q60875

MASS(Da):111974

GeneID:16800

Synonyms:Arhgef2 Kiaa0651 Lbcl1 Lfc

Gene names:Arhgef2

Standard solution:24ng/ml