Mouse Poly Adp Ribose Polymerase 2, PARP2 ELISA Kit

SKU: E2651Mo

Size:96 Tests-1 Kit

Background:Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed: 10364231). Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (By similarity). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity). Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 (By similarity). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site (By similarity). PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:PARP2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:12.28ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Poly Adp Ribose Polymerase 2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O88554

MASS(Da):63,397

GeneID:11546

Synonyms:ADP-ribosyltransferase diphtheria toxin-like 2;ADPRT-2;ARTD2;DNA ADP-ribosyltransferase PARP2;mPARP-2;NAD(+ ADP-ribosyltransferase 2;pADPRT-2;PARP 2;PARP2;PARP-2;Poly [ADP-ribose] polymerase 2;Poly[ADP-ribose] Synthase 2;Protein poly-ADP-ribosyltransferase PARP2;

Gene names:PARP2

Standard solution:8000ng/L