Mouse Niemann-Pick C1 protein,NPC1 ELISA KIT

SKU: E2308Mo

Size:96 Tests-1 Kit

Background:Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:21896731, PubMed:22048958, PubMed:27551080). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). {ECO:0000250|UniProtKB:O15118, ECO:0000269|PubMed:21896731, ECO:0000269|PubMed:22048958, ECO:0000269|PubMed:27551080, ECO:0000305}.

Research_area:

Applications:ELISA

Target_protein:Npc1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.55ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Niemann-Pick C1 protein

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O35604

MASS(Da):142885

GeneID:18145

Synonyms:Npc1

Gene names:Npc1

Standard solution:4800ng/L