Mouse Myosin Regulatory Light Chain 2, Ventricular, Cardiac Muscle Isoform, MYL2 ELISA Kit

SKU: E2282Mo

Size:96 Tests-1 Kit

Background:Contractile protein that plays a role in heart development and function (PubMed:10409661). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity) (PubMed:22426213, PubMed:16908724, PubMed:10409661). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (PubMed:9422794).

Research_area:Others

Applications:ELISA

Target_protein:MYL2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:5.59ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P51667

MASS(Da):18,864

GeneID:17906

Synonyms:Gm32672;Mlc;MLC-;MLC-2;MLC-2s/v;Mlc2v;MLC-2v;Myl;MYL2;Mylpc;Myosin light chain 2, slow skeletal/ventricular muscle isoform;Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

Gene names:Myl2

Standard solution:2400ng/L