Mouse LMBR1 Domain-containing Protein 1,LMBRD1 ELISA KIT

SKU: E1778Mo

Size:96 Tests-1 Kit

Background:Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (PubMed:24078630). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (PubMed:24078630). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (PubMed:27061115). {ECO:0000250|UniProtKB:Q9NUN5, ECO:0000269|PubMed:24078630, ECO:0000269|PubMed:27061115}.

Research_area:

Applications:ELISA

Target_protein:Lmbrd1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:1.19ng/L

Detection range:2-700ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:LMBR1 Domain-containing Protein 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8K0B2

MASS(Da):61062

GeneID:68421

Synonyms:Lmbrd1

Gene names:Lmbrd1

Standard solution:800ng/L