Mouse Junctional Adhesion Molecule C, JAM3 ELISA Kit

SKU: E2195Mo

Size:96 Tests-1 Kit

Background:Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed: 15372036, PubMed: 16093349). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed: 24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (PubMed: 16297198). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (PubMed: 15372036, PubMed: 15994945). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed: 16093349). Plays a role in angiogenesis (PubMed: 15994945). Plays a role in the regulation of cell migration (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis.

Research_area:Others

Applications:ELISA

Target_protein:JAM3

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:1.63ng/L

Detection range:3-900ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Junctional Adhesion Molecule C

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9D8B7

MASS(Da):34,838

GeneID:83964

Synonyms:JAM 3;JAM-2;JAM3;JAM-3;JAM-C;Junctional adhesion molecule 3;Junctional adhesion molecule C;sJAM-C;Soluble form of JAM-C;

Gene names:JAM3

Standard solution:960ng/L