Mouse Cytochrome Coxidase Subunit 4 Isoform 1, Mitochondrial, COX4I1 ELISA Kit

SKU: E1993Mo

Size:96 Tests-1 Kit

Background:Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Research_area:Tags & Cell Markers

Applications:ELISA

Target_protein:COX4I1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:34.45ng/L

Detection range:70-15000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P19783

MASS(Da):19,530

GeneID:12857

Synonyms:CO;COX;COX IV-1;Cox4;Cox4a;COX4I1;COXIV;Cytochrome c oxidase polypeptide IV;Cytochrome c oxidase subunit 4 isoform 1, mitochondrial;Cytochrome c oxidase subunit IV isoform 1;IV-1

Gene names:Cox4i1

Standard solution:16000ng/L