Mouse Cd160 Antigen, CD160 ELISA Kit

SKU: E1919Mo

Size:96 Tests-1 Kit

Background:Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (By similarity). Receptor for both classical and non-classical MHC class I molecules (PubMed:16177084). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (PubMed:25711213). On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (By similarity). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (PubMed:22801499). The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.

Research_area:Immunology

Applications:ELISA

Target_protein:CD160

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.055ng/mL

Detection range:0.1-40ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:CD160 antigen

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O88875

MASS(Da):20,570

GeneID:54215

Synonyms:AU045688;By55;CD antigen CD160;CD160;CD160 antigen;CD160 antigen, soluble form];Natural killer cell receptor BY55

Gene names:Cd160

Standard solution:48ng/mL