Mouse Bone Morphogenetic Protein 6, BMP6 ELISA Kit

SKU: E0774Mo

Size:96 Tests-1 Kit

Background:Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (By similarity). Plays also an important role in the regulation of iron metabolism by acting as a ligand for hemojuvelin/HJV (PubMed:19252486). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (By similarity).

Research_area:Signal Transduction; Cell Biology

Applications:ELISA

Target_protein:BMP6

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.05ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Bone Morphogenetic Protein 6

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P20722

MASS(Da):56,432

GeneID:12161

Synonyms:BMP6;BMP-6;Bone morphogenetic protein 6;D13Wsu115;D13Wsu115e;Vg;VG-1-related protein;Vgr1;VGR-1;

Gene names:Bmp6

Standard solution:4800ng/L