Mouse Bone Morphogenetic Protein 2,BMP2 ELISA KIT

SKU: E0770Mo

Size:96 Tests-1 Kit

Background:Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Stimulates also the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. {ECO:0000250|UniProtKB:P12643}.

Research_area:

Applications:ELISA

Target_protein:Bmp2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.82pg/ml

Detection range:18.75-1200pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Bone Morphogenetic Protein 2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P21274

MASS(Da):44525

GeneID:12156

Synonyms:Bmp2 Bmp-2

Gene names:Bmp2

Standard solution:2400pg/ml