Mouse Adenomatosis Polyposis Coli Protein, APC ELISA Kit

SKU: E0822Mo

Size:96 Tests-1 Kit

Background:Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization (By similarity).

Research_area:Cell Biology; Neuroscience; Epigenetics and Nuclear Signaling; Cancer

Applications:ELISA

Target_protein:APC

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:4.13ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Adenomatosis Polyposis Coli Protein

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q61315

MASS(Da):311,089

GeneID:11789

Synonyms:Adenomatous polyposis coli protein;AI047805;APC;AU020952;AW124434;CC1;mAPC;Min;Protein APC;

Gene names:Apc

Standard solution:1600ng/L