Mouse Acetyl-CoA, ACETYL-CoA ELISA Kit

SKU: E1809Mo

Size:96 Tests-1 Kit

Background:Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (Probable). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (PubMed:22534642). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:AcCoA

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.145ng/mL

Detection range:0.3-90ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:acetyl-CoA

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q920L1

MASS(Da):52,323

GeneID:76267

Synonyms:0710001O03Rik;8-3-desaturase;A930006B21Rik;AcCoA;Acyl-CoA;AI317215;D5D;Delta(5 desaturase;Delta(5 fatty acid desaturase;Delta-5 desaturase;DSD;Fatty acid desaturase 1

Gene names:Fads1

Standard solution:96ng/mL