MITF antibody , Cat. # FNab05198

SKU: FNab05198

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences(E-boxes)(5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase(TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase(TYR) and tyrosinase-related protein 1(TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

Immunogen:microphthalmia-associated transcription factor

Synonyms:bHLHe32, MI, MITF, WS2A

Observed MW:60-65kd

Uniprot ID:O75030

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, FC, IP

Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:2000

Gene ID:4286

Research Area:Epigenetics, Metabolism, Immunology, Developmental biology, Neuroscience