MINK1 Antibody - Cat. #: CSB-PA170472

SKU: CSB-PA170472

Size :100ul

Clone Number:

Aliases:MINK1 antibody; B55 antibody; MAP4K6 antibody; MINK antibody; YSK2 antibody; ZC3 antibody; Misshapen-like kinase 1 antibody; EC 2.7.11.1 antibody; GCK family kinase MiNK antibody; MAPK/ERK kinase kinase kinase 6 antibody; MEK kinase kinase 6 antibody; MEKKK 6 antibody; Misshapen/NIK-related kinase antibody; Mitogen-activated protein kinase kinase kinase kinase 6 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8N4C8

Immunogen:Synthesized peptide derived from internal of Human MAP4K6.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Dan I., FEBS Lett. 469:19-23(2000).
Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Olsen J.V., Cell 127:635-648(2006).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MINK1

Research Areas:Neuroscience;Signal transduction