MICU2 Antibody, FITC conjugated - Cat. #: CSB-PA818265LC01HU

SKU: CSB-PA818265LC01HU

Size :50ug

Clone Number:

Aliases:1110008L20Rik antibody; EF hand domain containing family member A1 antibody; EF hand domain family A1 antibody; EF hand domain family member A1 antibody; EF-hand domain-containing family member A1 antibody; EFHA1 antibody; EFHA1 EF hand domain family member A1 antibody; EFHA1_HUMAN antibody; FLJ25016 antibody; FLJ34588 antibody; Smhs2 homolog antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8IYU8

Immunogen:Recombinant Human Calcium uptake protein 2, mitochondrial protein (26-247AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MICU2

Research Areas:Cell biology