MGMT Antibody - Cat. #: CSB-PA821117

SKU: CSB-PA821117

Size :50ul

Clone Number:

Aliases:6 O methylguanine DNA methyltransferase antibody; 6-O-methylguanine-DNA methyltransferase antibody; Agat antibody; AGT antibody; AI267024 antibody; EC 2.1.1.63 antibody; Methylated DNA protein cysteine methyltransferase antibody; Methylated-DNA--protein-cysteine methyltransferase antibody; Methylguanine DNA methyltransferase antibody; MGC107020 antibody; MGMT antibody; MGMT_HUMAN antibody; O 6 methylguanine DNA alkyltransferase antibody; O 6 methylguanine DNA methyltransferase antibody; O-6-methylguanine-DNA methyltransferase antibody; O-6-methylguanine-DNA-alkyltransferase antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P16455

Immunogen:Fusion protein of Human MGMT

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; ELISA:1:1000-1:2000, WB:1:200-1:1000

Background:MGMT (O6-methylguanine-DNA methyltransferase) is transcriptionally activated in response to DNA damage and functions to repair mutagenic and cytotoxic O6-alkylguanine lesions caused by carcinogens or cytostatic drugs. MGMT induction by ionising radiation does not occur in p53-deficient mice, suggesting that MGMT induction may require p53. Similarly, MGMT mRNA and protein were shown to be inducible by ionising radiation, only in cell lines that express functional p53, and not in cell lines that do not express wild type p53. In contrast, high MGMT activity was associated with the presence of mutant p53, in a study of oral cancer cell lines. Similarly, MGMT activity was significantly lower in ovarian tumors with wildtype p53 than in tumors with mutant p53, supporting the view that wildtype p53 down-regulates the basal MGMT promoter.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MGMT

Research Areas:Epigenetics and Nuclear Signaling