MEK-5 rabbit pAb

SKU: ES20665

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF

Reactivity:Human;Mouse;Rat

Dilution:WB: 1:1000-2000 IHC: 1:200-500

Immunogen:Recombinant Protein of MEK-5

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:

Observed_band(KD):49kD

Human_gene_id:5067

Human_swiss_prot_no:Q13163

Subcellular_location:nucleus,cytoplasm,spindle,cytosol,

Other_name:MAP2K5; MEK5; MKK5; PRKMK5; Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPKK 5; MAPK/ERK kinase 5; MEK 5

Background:The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011],