MDM2 Polyclonal Antibody

SKU: E-AB-31995

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: MDM2

Target Synonym: ACTFS;Double minute 2 protein;E3 ubiquitin-protein ligase Mdm2;Hdm 2;Hdm2;HDMX;MDM 2;MDM2;MDM2 oncogene E3 ubiquitin protein ligase;Mdm2 p53 E3 ubiquitin protein ligase homolog;Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa;MDM2;MDM2BP;Mouse Double Minute 2;MTBP;Murine Double Minute Chromosome 2;Oncoprotein Mdm2;p53 Binding Protein Mdm2;p53-binding protein Mdm2;Ubiquitin protein ligase E3 Mdm2;Ubiquitin protein ligase E3 Mdm2

Research Areas: Cancer;Cell Biology;Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Monkey

Application: WB;IHC-p;IF

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q00987

Accession:

Background: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Concentration: 1 mg/mL

Immunogen: Synthesized peptide derived from human MDM2 around the non-phosphorylation site of Ser166.

Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Purification method: Affinity purification

Dilution: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000

Calculated MW: 55kDa

ObservedMW: 90kDa