MASTL Antibody, HRP conjugated - Cat. #: CSB-PA846629LB01HU

SKU: CSB-PA846629LB01HU

Size :50ug

Clone Number:

Aliases:2700091H24Rik antibody; C88295 antibody; FLJ14813 antibody; GREATWALL antibody; Greatwall protein kinase antibody; GW antibody; GWL antibody; GWL_HUMAN antibody; hGWL antibody; MAST-L antibody; Mastl antibody; MGC117975 antibody; Microtubule associated serine/threonine kinase like antibody; Microtubule-associated serine/threonine-protein kinase-like antibody; RP11 85G18.2 antibody; Serine/threonine-protein kinase greatwall antibody; THC2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96GX5

Immunogen:Recombinant Human Serine/threonine-protein kinase greatwall protein (612-740AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at \'Ser-62\' and \'Ser-67\', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MASTL

Research Areas:Signal transduction