Map2k5 Antibody - Cat. #: CSB-PA283905

SKU: CSB-PA283905

Size :100ul

Clone Number:

Aliases:Map2k5 antibody; Mek5 antibody; Mkk5 antibody; Prkmk5 antibody; Dual specificity mitogen-activated protein kinase kinase 5 antibody; MAP kinase kinase 5 antibody; MAPKK 5 antibody; EC 2.7.12.2 antibody; MAPK/ERK kinase 5 antibody; MEK 5 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Rattus norvegicus (Rat)

UniProt ID:Q62862

Immunogen:Peptide sequence around aa. 311-315(K-T-Y-V-G ) derived from Rat MEK5.

Raised in:Rabbit

Species Reactivity:Human, Rat, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phospho-rylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resem-bles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphory-late ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7)phosphorylates and activates the JNK signal transduction pathway.

Han, J., et al. 1996. J. Biol. Chem. 271: 2886-2891.
Jiang, Y., et al. 1996. J. Biol. Chem. 271: 17920-17926.
Tournier, C., et al. 1997. Proc. Natl. Acad. Sci. USA94: 7337-7442.
Holland, P.M., et al. 1997. J. Biol. Chem. 272: 24994-24998.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:Map2k5

Research Areas:Cancer?Cardiovascular;Signal transduction