M-CSF Receptor(Phospho-Tyr546) Rabbit Polyclonal Antibody

SKU: BT-AP11191

Size:100μL

Background:The protein encoded by this gene is the receptor for colony stimulating factor 1| a cytokine which controls the production| differentiation| and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants.

Research_area:Cancer; Cardiovascular; Cell biology; Immunology; Signal transduction; Stem cells

Target_protein:CSF1R

applications:WB

Reactivity:Human, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:M-CSF Receptor

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: P07333; Mouse: P09581; Rat: Q00495

Synonyms:M-CSF Receptor ;Tyr546; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; EC 2.7.10.1; Proto-oncogene c-Fms; CD antigen CD115

GeneID:Human: 1436; Mouse: 12978