LTA Antibody - Cat. #: CSB-PA013218KA01HU

SKU: CSB-PA013218KA01HU

Size :100ul

Clone Number:

Aliases:LTalpha antibody; DAMA-25N12.13-004 antibody; DIF antibody; LT alpha antibody; LT antibody; LT-alpha antibody; Lta antibody; Lymphotoxin alpha (TNF superfamily, member 1) antibody; Lymphotoxin alpha antibody; Lymphotoxin-alpha antibody; MGC117668 antibody; OTTHUMP00000037612 antibody; OTTHUMP00000037613 antibody; TNF B antibody; TNF superfamily member 1 antibody; TNF, lymphocyte-derived antibody; TNF-beta antibody; TNFB antibody; TNFB_HUMAN antibody; TNFbeta antibody; TNFSF 1 antibody; TNFSF1 antibody; TNLG1E antibody; Tumor necrosis factor beta antibody; tumor necrosis factor ligand 1E antibody; Tumor necrosis factor ligand superfamily member 1 antibody; tumor necrosis factor superfamily member 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P01374

Immunogen:Recombinant protein of Human LTA

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; WB:1:500-1:2000, IHC:1:50-1:200

Background:Lymphotoxin-? (LT-?), also known as TNF–?, is a member of the TNF superfamily of proteins. NK cells, T cells, B cells, and lymphoid tissue-inducer cells express LT-?. LT-? can be secreted as a soluble homotrimer or form membrane bound heterotrimers with lymphotoxin-? (LT ?1?2 or LT ?2?1) which can be cleaved from the cell surface by matrix metalloproteases. Soluble LT-? binds to and signals through TNFR1/TNFR2, activating the canonical NF-?B pathway. In contrast, LT ?1?2 heterodimers bind to the LT?R receptor and activate the noncanonical NF-?B pathway. As a result, LT-? and TNF-? have overlapping functions. Soluble LT-? and LT ?1?2 play key roles in lymphangiogenesis. The LT ?1?2/LT?R axis is essential for the development of lymphoid tissue.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Affinity purification

Conjugate:Non-conjugated

Buffer:Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:LTA

Research Areas:Cancer;Immunology;Signal transduction