LAT antibody , Cat. # FNab10030

SKU: FNab10030

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Required for TCR(T-cell antigen receptor)-and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3(low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1(high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Immunogen:linker for activation of T cells

Synonyms:LAT, LAT1, p36 38, pp36

Observed MW:36-38 kDa

Uniprot ID:O43561

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IHC

Recommended dilution:WB: 1:500-1:2000; IHC: 1:50-1:500

Gene ID:27040

Research Area:Immunology, Signal Transduction