KPNA2 Polyclonal Antibody

SKU: E-AB-19069

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: KPNA2

Target Synonym: IMA1;Importin alpha 1;Importin alpha 2;Importin alpha 2 subunit;Importin alpha P1;Importin subunit alpha-1;IPO A1;IPOA 1;IPOA1;Karyopherin alpha 2;Karyopherin alpha 2 RAG cohort 1;Karyopherin alpha 2 subunit;Karyopherin subunit alpha-2;KPNA2;KPNA2 protein;Pendulin;QIP 2;QIP2;RAG cohort 1;RAG cohort protein 1;RCH 1;RCH1;SRP 1;SRP1 alpha;SRP1;SRP1-alpha;SRP1alpha

Research Areas: Cancer;Immunology;Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P52292

Accession:

Background: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.

Concentration: 1.5 mg/mL

Immunogen: Fusion protein of human KPNA2

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: WB 1:1000-1:5000;IHC 1:50-1:300

Calculated MW: 58 kDa

ObservedMW: Refer to figures